International researchers summarize the current understanding of peptic disease and trace the development of a novel new drug for peptic disease therapy-sucralfate. Contributors present laboratory research along side data from clinical trials as well as from the practice of medicine. Articles discuss the history of sucralfate's development, mechanisms of action, clinical efficacy, and future directions for research. This volume will be of interest to scientists and clinicians working in gastroenterology and gastrointestinal physiology. Front Matter....Pages i-xxiv Pathophysiology of Peptic Ulcer Disease....Pages 1-13 Decreased Intragastric Acid Concentration as an Approach to Peptic Disease Therapy....Pages 15-23 Ulcer Healing by Strengthening of Mucosal Defense....Pages 25-34 History of the Development of Sucralfate....Pages 35-45 Chemistry of Sucralfate....Pages 47-58 Binding of Bile Acids by Sucralfate....Pages 59-70 Binding of Sucralfate to the Mucosal Surface....Pages 71-82 Stimulation of Mucus Production....Pages 83-88 Gastroduodenal Bicarbonate Secretion and its Response to Sucralfate....Pages 89-101 Effect of Sucrose Octasulfate on Isolated Gastric Cells....Pages 103-109 Effect on Gastric Surfactant....Pages 111-126 Stimulation of Mucosal Prostaglandins by Sucralfate....Pages 127-132 Sucralfate and Helicobacter pylori ....Pages 133-140 Sucralfate and Cell Proliferation....Pages 141-149 Vascular Factors....Pages 151-162 Sucralfate....Pages 163-173 Effects of Sucralfate on Growth Factor Availability....Pages 175-189 Duodenal Ulcer Therapy, “Acid Rebound,” and Early Relapse....Pages 191-196 Effect of Sucralfate on Experimental Ulcers....Pages 197-207 Effect on Experimental Esophageal Injury....Pages 209-214 Safety of Sucralfate....Pages 215-224 Sucralfate Drug Interaction Studies....Pages 225-238 Therapy of Gastric Ulcer Disease....Pages 239-247 Therapy of Active Duodenal Ulcers....Pages 249-255 Prevention of Ulcer Recurrence....Pages 257-270 Therapy of Esophagitis....Pages 271-276 Sucralfate for NSAID-Induced Gastroduodenal Lesions....Pages 277-288 Sucralfate for Prevention of Acute Gastrointestinal Bleeding....Pages 289-301 Prevention of Respiratory Tract Infections with Sucralfate in Ventilated ICU Patients....Pages 303-315 Sucralfate in Nonulcer Dyspepsia, Gastritis, and Duodenitis....Pages 317-322 Use of Sucralfate in Variceal Sclerotherapy-Induced Ulcerations....Pages 323-331 Future Research into the Mechanisms of Action of Sucralfate....Pages 333-337 Future Clinical Development of Sucralfate....Pages 339-349 Back Matter....Pages 351-366
