"Recent work has begun to elucidate at the molecular level how albumin is handled by the kidney and how albuminuria develops in various proteinuric diseases including minimal change disease and focal segmental glomerulosclerosis. This volume provides a comprehensive overview of the renal handling of albumin - from basic mechanisms to the pathophysiology of proteinuric diseases. In describing the basic mechanisms of albuminuria, a particular highlight will be the focus on advanced imaging techniques such as intravital microscopy that have allowed a detailed "window" into albumin transit through the kidney. The volume will cover the epidemiological studies which show that albuminuria is a strong and independent marker of kidney disease progression and cardiovascular events, the molecular details of albumin handling in the kidney at the level of the glomerulus and the proximal tubule and the pathophysiology of proteinuric diseases including minimal change disease, membranous nephropathy, focal segmental glomerulosclerosis and diabetic nephropathy." - Font no determinada Recent work has begun to elucidate at the molecular level how albumin is handled by the kidney and how albuminuria develops in various proteinuric diseases including minimal change disease and focal segmental glomerulosclerosis. This volume provides a comprehensive overview of the renal handling of albumin {u2013} from basic mechanisms to the pathophysiology of proteinuric diseases. In describing the basic mechanisms of albuminuria, a particular highlight will be the focus on advanced imaging techniques such as intravital microscopy that have allowed a detailed 2window3 into albumin transit through the kidney. The volume will cover the epidemiological studies which show that albuminuria is a strong and independent marker of kidney disease progression and cardiovascular events, the molecular details of albumin handling in the kidney at the level of the glomerulus and the proximal tubule and the pathophysiology of proteinuric diseases including minimal change disease, membranous nephropathy, focal segmental glomerulosclerosis and diabetic nephropathy Introduction -- Contents -- Chapter 1: Evaluation and Epidemiology of Proteinuria -- 1.1 Measurement of Proteinuria -- 1.2 Epidemiology -- 1.3 Evaluation of the Individual with Proteinuria -- 1.4 Treatment -- 1.5 Summary -- References -- Chapter 2: Glomerular Mechanisms of Proteinuria -- 2.1 Introduction -- 2.2 Structure of the Glomerulus -- 2.3 Podocyte Structure and Function -- 2.4 Summary -- References -- Chapter 3: Tubular Mechanisms in Proteinuria -- 3.1 Introduction -- 3.2 Tubular Handing of Proteins -- 3.3 PTC and Albumin Reabsorption -- 3.3.1 Endocytosis by Proximal Tubule Front Matter....Pages i-vii Evaluation and Epidemiology of Proteinuria....Pages 1-9 Glomerular Mechanisms of Proteinuria....Pages 11-21 Tubular Mechanisms in Proteinuria....Pages 23-40 Pathophysiology of Diabetic Nephropathy....Pages 41-65 Immune-Mediated Mechanisms of Proteinuria....Pages 67-84 Minimal Change Disease....Pages 85-116 Focal Segmental Glomerulosclerosis and Its Pathophysiology....Pages 117-139 Back Matter....Pages 141-145
