Brain Ischemia : Basic Concepts and Clinical Relevance

Professor Caplan has extensively edited the book to shape and organize the contents into a succinct presentation by experts of the basic science and clinical aspects of the topic. The text has been divided into sections: The Brain.- Macroscopic and microscopic molecular aspects of brain ischemia, including pathophysiology, pathology, biochemistry, and clinical measurement.- Blood Vessels.- Their constitution and the pathology and physiology of the endothelium and arterial wall.- Blood Flow.- Its physics, control, rheology, and pathophysiology.- Blood.- The role of the cellular and serological constituents in coagulation and fibrinolysis. - Heart.- Sources of embolism and cardiac changes caused by brain ischemia.- And Epidemiology, Databases, and Trials. Prefatory remarks by Professor Caplan introduce each section. At the end of each section he relates the basic concepts to patient problems in the clinic, integrates the various contributions in the section, and covers other areas not discussed by the individual contributors. Front Matter....Pages i-xiii Front Matter....Pages 1-1 Prefatory Comments....Pages 3-6 Mechanisms of Cell Death in Ischemia....Pages 7-18 Positron Emission Tomography (PET) in Acute Ischemic Stroke: Pathophysiological and Clinical Implications....Pages 19-27 Excitotoxicity and Stroke....Pages 29-36 Growth Factors in Stroke....Pages 37-41 Ischemic Cerebral Edema....Pages 43-50 Concluding Comments....Pages 51-56 Front Matter....Pages 57-57 Prefatory Comments....Pages 59-60 Ocular Ischemia....Pages 61-73 Concluding Comments....Pages 75-79 Front Matter....Pages 81-81 Prefatory Comments....Pages 83-84 Coagulation....Pages 85-96 Immunohematologic Mechanisms in Stroke....Pages 97-103 Fibrinolysis and its Relevance to Acute Focal Cerebral Ischemia....Pages 105-119 Concluding Comments....Pages 121-126 Front Matter....Pages 127-127 Prefatory Comments....Pages 129-133 Atherosclerosis....Pages 135-150 Cerebral Vasoconstriction: Physiology, Pathophysiology and Occurrence in Selected Cerebrovascular Disorders....Pages 151-172 Endothelial Cells and Cerebrovascular Disease....Pages 173-183 Physical Factors in the Pathogenesis of Atheroma Formation....Pages 185-213 Front Matter....Pages 127-127 Microvascular Pathology....Pages 215-222 Concluding Comments....Pages 223-231 Front Matter....Pages 233-233 Prefatory Comments....Pages 235-236 Autoregulation, Hypertension and Regulation of the Cerebral Circulation....Pages 237-245 The Innervation of Pial Blood Vessels and their Role in Cerebrovascular Regulation....Pages 247-259 Rheology of Flow and its Effects....Pages 261-267 Pathophysiology of Raised Intracranial Pressure....Pages 269-272 Central Neurogenic Regulation of Regional Cerebral Blood Flow (rCBF) and Relationship to Neuroprotection....Pages 273-288 Concluding Comments....Pages 289-294 Front Matter....Pages 295-295 Prefatory Comments....Pages 297-298 Cardiac Disease and Embolic Sources....Pages 299-315 Heart and Brain Relationships....Pages 317-328 Concluding Comments....Pages 329-334 Front Matter....Pages 335-335 Prefatory Comments....Pages 337-341 Epidemiology and Trials....Pages 343-353 Stroke Data Banks and Stroke Registries....Pages 355-363 Concluding Comments....Pages 365-368 Back Matter....Pages 369-380 Presents an overview of current practice in the care of stroke patients, as well as a summary of the history of stroke research.