Testosterone : From Basic to Clinical Aspects

Research on testosterone is increasing in many senses; however there is still much controversy regarding its physiology and clinical use. This book addresses these topics, providing a broad over­view about testosterone, from its basic fea­tures to the most recent evidence of clin­ical applicability. Also, specific conditions in which testosterone play a pivotal role are discussed in detail, such as hypogonadism, misuse and abuse, puberty, cardiovascular effects and testosterone therapy. Although not essential for survival, testosterone represents the essence of male biological function, being the important testicular androgen in men. Low serum testosterone levels are asso­ciated with cardiovascular morbidity, meta­bolic syndrome, type 2 diabetes mellitus, atherosclerosis, osteoporosis, sarcopenia, and mortality. Conversely, increased serum levels of testosterone may lead to deleteri­ous events. In general, there is increasing evidence that serum testosterone is a major biomarker status of men’s health in general. __Testosterone: From Basic to Clinical Aspects__ is an indispensable reference for all those who seek state-of-the-art knowledge regarding this hormone, from basic issues (including pharma­cology and physiology) through clinical aspects (related diseases and supplementation ther­apy). Research on testosterone is increasing in many senses; however there is still much controversy regarding its physiology and clinical use. This book addresses these topics, providing a broad overƯview about testosterone, from its basic feaƯtures to the most recent evidence of clinƯical applicability. Also, specific conditions in which testosterone play a pivotal role are discussed in detail, such as hypogonadism, misuse and abuse, puberty, cardiovascular effects and testosterone therapy. Although not essential for survival, testosterone represents the essence of male biological function, being the important testicular androgen in men. Low serum testosterone levels are assoƯciated with cardiovascular morbidity, metaƯbolic syndrome, type 2 diabetes mellitus, atherosclerosis, osteoporosis, sarcopenia, and mortality. Conversely, increased serum levels of testosterone may lead to deleteriƯous events. In general, there is increasing evidence that serum testosterone is a major biomarker status of mens health in general. Testosterone : From Basic to Clinical Aspects is an indispensable reference for all those who seek state-of-the-art knowledge regarding this hormone, from basic issues (including pharmaƯcology and physiology) through clinical aspects (related diseases and supplementation therƯapy) Front Matter....Pages i-xiii The History of Testosterone and The Testes: From Antiquity to Modern Times....Pages 1-19 Androgen Receptor in Health and Disease....Pages 21-73 Physiology of Male Gonadotropic Axis and Disorders of Sex Development....Pages 75-96 Utility and Limitations in Measuring Testosterone....Pages 97-107 Male Puberty: What Is Normal and Abnormal?....Pages 109-132 Hypogonadotropic and Hypergonadotropic Hypogonadism....Pages 133-145 Functional Hypogonadism: Diabetes Mellitus, Obesity, Metabolic Syndrome, and Testosterone....Pages 147-159 Male Hypogonadism and Aging....Pages 161-188 Hypogonadism After Traumatic Brain Injury....Pages 189-202 Testosterone Therapy: Oral Androgens....Pages 203-224 Testosterone Therapy: Transdermal Androgens....Pages 225-235 Testosterone Therapy: Injectable Androgens....Pages 237-251 Benefits and Adverses Effects of Testosterone Therapy....Pages 253-269 Testosterone and Sexual Function....Pages 271-284 Testosterone Therapy and Prostate Cancer....Pages 285-297 Testosterone and Cardiovascular Effects....Pages 299-318 Testosterone and Women....Pages 319-351 Testosterone and Endocrine Disruptors: Influence of Endocrine Disruptors on Male Reproductive Tract....Pages 353-374 Testosterone Misuse and Abuse....Pages 375-402 Back Matter....Pages 403-414