Stem cells are the building blocks of the body. They can develop into any of the cell types that make up our bodies. During development, they contribute to the formation of the tissues. In the adult, they contribute to homeostasis of the tissues and regeneration after injury. Stem cells carry a lot of hope for the treatment of a broad range of diseases and injuries, spanning from neurological diseases and injuries, like Alzheimer's disease, Parkinson's disease and spinal cord injuries, to diabetes, genetic diseases, graft-versus-host diseases, eye, heart and liver diseases, inflammatory and autoimmune disorders, and cancers. Stem cell research is therefore as important for our understanding of development, physio- and pathology of the body, as for therapy. "Stem Cells" aims at providing an overview and in depth analysis of recent developments in stem cell research and therapy. It is composed of recently published review articles that encompass the field of stem cell research and regenerative medicine. All the articles went through peer-review process. "Stem cells are the building blocks of the body. They can develop into any of the cell types that make up our bodies. During development, they contribute to the formation of the tissues. In the adult, they contribute to homeostasis of the tissues and regeneration after injury. Stem cells carry much hope for the treatment of a broad range of diseases and injuries, ranging from neurological diseases and injuries, sich as Alzheimer's disease, Parkinson's disease and spinal cord injuries, to diabetes, genetic diseases, graft-versus-host diseases, eye, heart and liver diseases, inflammatory and autoimmune disorders, and cancers. Stem cell research is, therefore, as important for our understanding of the development, physio- and pathology of the body as it is for therapy." "Stem Cells aims at providing an overview and in-depth analysis of recent developments in stem cell research and therapy. It is composed of recently-published review articles that encompass the field of stem cell research and regenerative medicine. All of the articles went through a peer-review process."--BOOK JACKET STEM CELLS 3 STEM CELLS 5 CONTENTS 7 PREFACE 9 ADULT NEURAL STEM CELLS: A PROMISING CANDIDATE FOR REGENERATIVE THERAPY IN THE CNS 11 NEURAL PROGENITOR AND STEM CELLS IN THE ADULT CENTRAL NERVOUS SYSTEM 25 NEUROGENESIS IN THE ADULT CENTRAL NERVOUS SYSTEM 39 BRDU IMMUNOHISTOCHEMISTRY FOR STUDYING ADULT NEUROGENESIS: PARADIGMS, PITFALLS, LIMITATIONS AND VALIDATION 57 DERIVATION OF EMBRYONIC STEM CELLS FOR CELLULAR THERAPY: CHALLENGES AND NEW STRATEGIES 89 OTI-010 OSIRIS THERAPEUTICS/JCR PHARMACEUTICALS 97 ADULT NEURAL STEM CELLS, NEUROGENIC NICHES AND CELLULAR THERAPY 115 THE THERAPEUTIC POTENTIAL OF ADULT NEURAL STEM CELLS 129 STEM CELLS ENGINEERING FOR CELL-BASED THERAPY 143 ADULT NEUROGENESIS PHARMACOLOGY IN NEUROLOGICAL DISEASES AND DISORDERS 153 ADULT NEUROGENESIS, NEUROINFLAMMATION AND THERAPEUTIC POTENTIAL OF ADULT NEURAL STEM CELLS 171 ADULT NEUROGENESIS AND NEUROPLASTICITY 183 HUCNS-SC STEM CELLS 195 CONCLUSION AND PERSPECTIVES 210 INDEX 217 1606922149,9781606922149 Nova Science Publishers Neural progenitor and stem cells in the adult central nervous system Neurogenesis in the adult central nervous system BrdU immunohistochemistry for studying adult neurogenesis : paradigms, pitfalls, limitations, and validation Derivation of embryonic stem cells for cellular therapy : challenges and new strategies OTI-010 osiris therapeutics/JCR pharmaceuticals Adult neural stem cells, neurogenic niches, and cellular therapy The therapeutic potential of adult neural stem cells Stem cells engineering for cell-based therapy Adult neurogenesis pharmacology in neurological diseases and disorders Adult neurogenesis, neuroinflammation and therapeutic potential of adult neural stem cells Adult neurogenesis and neuroplasticity HuCNS-SC stemcells. Conclusion & perspectives : stem cells from non-viable versus post-mortem tissues. Adult neural stem cells from promise to treatment : the road ahead.
