Immunopharmacology

__Immunopharmacology__ focuses on the mechanism of action of pharmacologic agents that regulate immune response and the physiologic, pathologic, and pharmacologic role of the products of immune response. Topics include cytokines and their receptors, immunosuppressive drugs, monoclonal antibodies, mechanisms and immunotherapy of allergic disease, clinical transplantation, acquired immune deficiency disease, regulatory T cells, and gene therapy. The book provides most basic principles of immunopharmacology by equally emphasizing the disciplines of immunology and pharmacology, which will be a very valuable tool for both the professional as well as graduate students. During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology. "Immunopharmacology focuses on the mechanism of action of pharmacologic agents that regulate immune response and the physiologic, pathologic, and pharmacologic role of the products of immune response. Topics include cytokines and their receptors, immunosuppressive drugs, monoclonal antibodies, mechanisms and immunotherapy of allergic disease, clinical transplantation, acquired immune deficiency disease, regulatory T cells, and gene therapy. The book provides most basic principles of immunopharmacology by equally emphasizing the disciplines of immunology and pharmacology, which will be a very valuable tool for both the professional as well as graduate students."--BOOK JACKET Front Matter....Pages i-xiv Overview of the Immune Response....Pages 1-32 Role of Cytokines....Pages 33-59 Cytokine Receptors and Signaling....Pages 61-86 Immunosuppressive Agents....Pages 87-105 Monoclonal Antibodies as Therapeutic Agents....Pages 107-126 Allergic Disease....Pages 127-147 Tissue Transplantation....Pages 149-170 Acquired Immune Deficiency Syndrome....Pages 171-201 Regulatory T Cells and Disease State....Pages 203-226 Gene Therapy....Pages 227-252 Back Matter....Pages 253-266 Overview Of The Immune Response -- Role Of Cytokines -- Cytokine Receptors And Signaling -- Immunosuppressive Agents -- Monoclonal Antibodies As Therapeutic Agents -- Allergic Disease -- Tissue Transplantation -- Acquired Immune Deficiency Syndrome -- Regulatory T Cells And Disease State -- Gene Therapy. Manzoor M. Khan. Includes Bibliographical References And Index.