This significant book conveys Dr. William E. Paul’s enduring enthusiasm for the field of immunology, the incredible accomplishments of the past half-century, and the future’s untapped promises. The immune system has incredible power to protect us from the ravages of infection by killing disease-causing microbes or eliminating them from the body. Boosted by vaccines, it can protect us individually and as a "herd" from diseases such as measles. As Dr. Paul explains, however, the power of the immune system is a double-edged sword: an overactive immune system can wreak havoc, destroying normal tissue and causing diseases such as type I diabetes, rheumatoid arthritis, and multiple sclerosis. The consequences of an impaired immune system, on the other hand, are all too evident in the clinical agonies of AIDS and other immunodeficiency diseases. Packed with illustrations, stories from Dr. Paul’s distinguished career, and compelling narratives of scientific discovery, Immunity presents the three laws of the human immune system―universality, tolerance, and appropriateness―and explains how the system protects and harms us. From the tale of how smallpox was overcome to the lessons of the Ebola epidemic to the utility of vaccines and the hope that the immune system can be used to treat or prevent cancer, Dr. Paul argues that we must position ourselves to take advantage of cutting-edge technologies and promising new tools in immunological research, including big data and the microbiome. The Immune System Has Incredible Power To Protect Us From The Ravages Of Infection. Boosted By Vaccines, It Can Protect Us Individually And As A Herd From Diseases Such As Measles. However, The Power Of The Immune System Is A Double-edged Sword: An Overactive Immune System Can Wreak Havoc, Destroying Normal Tissue And Causing Diseases Such As Type I Diabetes, Rheumatoid Arthritis, And Multiple Sclerosis. The Consequences Of An Impaired Immune System, On The Other Hand, Are All Too Evident In The Clinical Agonies Of Aids. Packed With Illustrations, Stories From Dr. William E. Paul's Distinguished Career, And Fascinating Accounts Of Scientific Discovery, Immunity Presents The Three Laws Of The Human Immune System--universality, Tolerance, And Appropriateness--and Explains How The System Protects And Harms Us. From The Tale Of How Smallpox Was Overcome And The Lessons Of The Ebola Epidemic To The Hope That The Immune System Can Be Used To Treat Or Prevent Cancer, Dr. Paul Argues That We Must Take Advantage Of Cutting-edge Technologies And Promising New Tools In Immunological Research.--book Jacket. Part 1. Immunology -- 1. Defense And Danger -- 2. Tracing An Immune Response -- 3. The Laws Of Immunology: Universality, Tolerance, And Appropriateness -- 4. Growing Up And Learning Immunology -- Part 2. The First Law: Universality -- 5. Vaccines And Serum Therapy -- 6. How Is Specificity Achieved? -- 7. Immunology's Eureka: Clonal Selection -- 8. How Does Each Lymphocyte Develop A Distinct Receptor? -- 9. B Cells And T Cells Recognize Different Types Of Antigens -- 10. My Foray Into The Specificity Problem -- 11. Genes And Immune Response -- 12. The Laboratory Of Immunology And The T-cell Receptor -- Part 3. The Second Law: Tolerance -- 13. What Is Tolerance? -- 14. How Does Tolerance Develop? -- 15. Regulatory T Cells And The Prevention Of Autoimmunity -- Part 4. The Third Law: Appropriateness -- 16. Different Structures, Different Functions -- 17. Specific Types Of Infections, Specific Types Of T-cell Responses -- 18. Our Discovery Of Il-4 And The Cells That Make It -- 19. Cd8 T Cells: Killer Cells And Friends -- 20. Dendritic Cells: The Cells That Interpret The Infectious Threat -- Part 5. How Did The Immune System Evolve? -- 21. An Ancient Immune Response Controls Modern Immunity -- 22. The Microbiome And Innate Immunity -- 23. Evolution Of The Immune System And Innate Lymphoid Cells -- Part 6. Aids, Autoimmunity, Allergy, Cancer, And Transplantation -- 24. The Hiv Epidemic And The Office Of Aids Research -- 25. How The Immune System Causes Rheumatoid Arthritis And Lupus -- 26. Allergy And Asthma -- 27. Interleukin-4 And Allergy -- 28. Can The Immune System Control Cancer? -- 29. New Parts For Old: Bone Marrow And Organ Transplantation -- 30. Julien -- Conclusion. The Future Of Immunology. William E. Paul. Includes Bibliographical References And Index. A leading figure in immunology takes readers inside the remarkably powerful human immune system. Winner of the CHOICE Outstanding Academic Title of the Choice ACRL The immune system has incredible power to protect us from the ravages of infection. Boosted by vaccines, it can protect us from diseases such as measles. However, the power of the immune system is a double-edged sword: an overactive immune system can wreak havoc, destroying normal tissue and causing diseases such as type I diabetes, rheumatoid arthritis, and multiple sclerosis. The consequences of an impaired immune system, on the other hand, are all too evident in the agonies of AIDS. Packed with illustrations, stories from Dr. William E. Paul's distinguished career, and fascinating accounts of scientific discovery, Immunity presents the three laws of the human immune system—universality, tolerance, and appropriateness—and explains how the system both protects and harms us. From the tale of how smallpox was overcome and the lessons of the Ebola epidemic to the hope that the immune system can be used to treat or prevent cancer, Dr. Paul argues that we must take advantage of cutting-edge technologies and promising new tools in immunological research.
The immune system has incredible power to protect us from the ravages of infection. Boosted by vaccines, it can protect us from diseases such as measles. However, the power of the immune system is a double-edged sword: an overactive immune system can wreak havoc, destroying normal tissue and causing diseases such as type I diabetes, rheumatoid arthritis, and multiple sclerosis. The consequences of an impaired immune system, on the other hand, are all too evident in the agonies of AIDS.
Packed with illustrations, stories from Dr. William E. Paul’s distinguished career, and fascinating accounts of scientific discovery, Immunity presents the three laws of the human immune system—universality, tolerance, and appropriateness—and explains how the system both protects and harms us. From the tale of how smallpox was overcome and the lessons of the Ebola epidemic to the hope that the immune system can be used to treat or prevent cancer, Dr. Paul argues that we must take advantage of cutting-edge technologies and promising new tools in immunological research.
This significant book conveys Dr. William E. Paul’s enduring enthusiasm for the field of immunology, the incredible accomplishments of the past half-century, and the future’s untapped promises. Packed with illustrations, stories from Dr. Paul’s distinguished career, and compelling narratives of scientific discovery, __Immunity__ presents the three laws of the human immune system―universality, tolerance, and appropriateness―and explains how the system protects and harms us. From the tale of how smallpox was overcome to the lessons of the Ebola epidemic to the utility of vaccines and the hope that the immune system can be used to treat or prevent cancer, Dr. Paul argues that we must position ourselves to take advantage of cutting-edge technologies and promising new tools in immunological research, including big data and the microbiome.
