book is quite complete in scope... The numerous illustrations are remarkably well crafted, even gorgeous. The attention so obviously devoted by the authors and editors to these explanatory illustrations is esthetically rewarding and will be particularly valuable to readers with little background in developmental biology...Serious scholars and investigators in the field will want this book because it is the mose accessible, authoritative, and complete summary of cardiac development currently available, one that can serve as a reference for themselves, their students, and their laboratory personnel...the sheer beauty of the book, the usefulness of the index, and the clarity of the illustrations should provide both information and pleasure to a broad readership.'' --NEW ENGLAND JOURNAL OF MEDICINE (April 1999) '' Heart Development is therefore timely and important, and fills a void in the available literature... Often such volumes are so long in the making that they are out of date before they are published. Not this book. With up-to-date chapters written by many recognized authorities in the field of cardiac development, and clear, high quality illustrations (a particularly strong feature), the book will be valuable to graduate students, investigators in the basic sciences, and clinicians wishing to stay current in this field.'' --NATURE MEDICINE (March 1999) ''The 28 chapters in Heart Development are very well written. The book is beautifully produced and contains many excellent diagrams... The volume is indispensable for those who work on the heart...'' --SCIENCE (February 1999) Content: Contributors , Pages xiii-xv Preface , Page xvii , Nadia Rosenthal, Richard P. Harvey Introduction , Pages xix-xx , Christine Seidman 1 - Cardiac Fate Maps: Lineage Allocation, Morphogenetic Movement, and Cell Commitment , Pages 3-18 , Patrick P.L. Tam, Gary C. Schoenwolf 2 - Cardiac Lineages , Pages 19-33 , Takashi Mikawa 3 - Heart Formation and the Heart Field in Amphibian Embryos , Pages 37-49 , Timothy J. Mohun, Li Ming Leong 4 - Vertebrate Heart Induction , Pages 51-62 , Thomas M. Schultheiss, Andrew B. Lassar 5 - Genetic Determination of Drosophila Heart Development , Pages 65-90 , Rolf Bodmer, Manfred Frasch 6 - Mutations Affecting Cardiac Development in Zebrafish , Pages 91-110 , Jonathan Alexander, Didier Y.R. Stainier 7 - Transcriptional Control and Pattern Formation in the Developing Vertebrate Heart: Studies on NK-2 Class Homeodomain Factors , Pages 111-129 , Richard P. Harvey, Christine Biben, David A. Elliott 8 - Control of Cardiac Development by the MEF2 Family of Transcription Factors , Pages 131-142 , Brian L. Black, Eric N. Olson 9 - Segmental Regulation of Cardiac Development by the Basic Helix-Loop-Helix Transcription Factors dHAND and eHAND , Pages 143-155 , Deepak Srivastava 10 - Mechanisms of Segmentation, Septation, and Remodeling of the Tubular Heart: Endocardial Cushion Fate and Cardiac Looping , Pages 159-177 , Corey H. Mjaatvedt, Hideshi Yamamura, Andy Wessels, Anne Ramsdell, Debi Turner, Roger R. Markwald 11 - Contribution of Neural Crest to Heart and Vessel Morphology , Pages 179-193 , Margaret L. Kirby 12 - Development of the Conduction System of the Vertebrate Heart , Pages 195-207 , Antoon F.M. Moorman, Wouter H. Lamers 13 - Retinoids in Heart Development , Pages 209-219 , Steven W. Kubalak, Henry M. Sucov 14 - Molecular Mechanisms of Vascular Development , Pages 221-252 , Ondine Cleaver, Paul A. Krieg 15 - The MLC-2 Paradigm for Ventricular Heart Chamber Specification, Maturation, and Morphogenesis , Pages 255-272 , Vân Thi Bich Nguyêñ-Trân, Ju Chen, Pilar Ruiz-Lozano, Kenneth Randall Chien 16 - Serum Response Factor- NK Homeodomain Factor Interactions, Role in Cardiac Development , Pages 273-290 , James M. Reecy, Narasimhaswamy S. Belaguli, Robert J. Schwartz 17 - GATA Transcription Factors and Cardiac Development , Pages 291-306 , Michael S. Parmacek, Jeffrey M. Leiden 18 - Multiple Layers of Control in Transcriptional Regulation by MCAT Elements and the TEF-1 Protein Family , Pages 307-329 , Sarah B. Larkin, Charles P. Ordahl 19 - Regionalization of Transcriptional Potential in the Myocardium , Pages 333-355 , Robert G. Kelly, Diego Franco, Antoon F.M. Moorman, Margaret Buckingham 20 - Chamber-Specific Gene Expression and Regulation during Heart Development , Pages 357-369 , Gang Feng Wang, Frank E. Stockdale 21 - Establishing Cardiac Left-Right Asymmetry , Pages 373-389 , H. Joseph Yost 22 - Left-Right Asymmetry and Cardiac Looping , Pages 391-402 , Kumud Majumder, Paul A. Overbeek 23 - The Cardiac Cell Cycle , Pages 405-427 , W. Robb MacLellan, Michael D. Schneider 24 - Regulation of Vascular Smooth Muscle Differentiation and Cell Cycle , Pages 429-443 , Kenneth Walsh, Harris R. Perlman, Roy C. Smith 25 - Symmetry and Laterality in the Human Heart: Developmental Implications , Pages 447-461 , Nigel A. Brown, Robert H. Anderson 26 - The Genetic Basis of Conotruncal Cardiac Defects: The Chromosome 22q11.2 Deletion , Pages 463-478 , Beverly S. Emanuel, Marcia L. Budarf, Peter J. Scambler 27 - Genetics of Human Left-Right Axis Malformations , Pages 479-489 , Brett Casey, Kenjiro Kosaki 28 - Molecular Genetics of Skeletal Muscle Development , Pages 493-517 , Michael J. McGrew, José Xavier-Neto, Olivier Pourquie, Nadia Rosenthal Index , Pages 519-530 This book examines recent studies revealing that the same genes are responsible for development of parallel features between species, and that the heart develops similarly across all species. It includes research being conducted concerning cardiac development, tissue interaction, and organ formation. The text attempts to provide a greater understanding of the underlying causes of heart failure, heart muscle diseases, congenital malformations, and other heart diseases and defects. Key Features\* Each chapter has been solicited from a recognized leader in the field, and covers a topic of active research in cardiovascular biology\* Chapters incorporate a review of classical findings with comprehensive coverage of the latest advances\* Abundant color plates in a consistent and professional artistic style provide clear and attractive illustrations of central concepts\* Color slides of illustrations for seminars or teaching purposes are available with each volume Origins And Early Morphogenesis -- Cardiac Induction -- Genetic Dissection Of Heart Development -- Normal And Abnormal Morphogenesis -- Genetic Control Of Muscle Gene Expression -- Heart Patterning: The Anterior-posterior Axis -- Heart Patterning: Left-right Asymmetry -- Cell Proliferation In Cardiovascular Development And Disease -- Human Cardiac Development Defects -- Lessons From Skeletal Muscle. Edited By Richard P. Harvey, Nadia Rosenthal. Includes Bibliographical References And Index. This book examines recent studies revealing that the same genes are responsible for development of parallel features between species, and the heart develops exactly the same in all species. It includes research being conducted concerning cardiac development, tissue interaction, and organ formation. The text attempts to provide a greater understanding of the underlying causes of heart failure, heart muscle diseases, congenital malformations, and other heart diseases and defects.