Data Mining for Bioinformatics

Covering theory, algorithms, and methodologies, as well as data mining technologies, **Data Mining for Bioinformatics** provides a comprehensive discussion of data-intensive computations used in data mining with applications in bioinformatics. It supplies a broad, yet in-depth, overview of the application domains of data mining for bioinformatics to help readers from both biology and computer science backgrounds gain an enhanced understanding of this cross-disciplinary field. The book offers authoritative coverage of data mining techniques, technologies, and frameworks used for storing, analyzing, and extracting knowledge from large databases in the bioinformatics domains, including genomics and proteomics. It begins by describing the evolution of bioinformatics and highlighting the challenges that can be addressed using data mining techniques. Introducing the various data mining techniques that can be employed in biological databases, the text is organized into four sections: 1. Supplies a complete overview of the evolution of the field and its intersection with computational learning 2. Describes the role of data mining in analyzing large biological databases—explaining the breath of the various feature selection and feature extraction techniques that data mining has to offer 3. Focuses on concepts of unsupervised learning using clustering techniques and its application to large biological data 4. Covers supervised learning using classification techniques most commonly used in bioinformatics—addressing the need for validation and benchmarking of inferences derived using either clustering or classification The book describes the various biological databases prominently referred to in bioinformatics and includes a detailed list of the applications of advanced clustering algorithms used in bioinformatics. Highlighting the challenges encountered during the application of classification on biological databases, it considers systems of both single and ensemble classifiers and shares effort-saving tips for model selection and performance estimation strategies. "PREFACE The flourishing field of bioinformatics has been the catalyst to transform biological research paradigms to extend beyond traditional scientific boundaries. Fueled by technological advancements in data collection, storage and analysis technologies in biological sciences, researchers have begun to increasingly rely on applications of computational knowledge discovery techniques to gain novel biological insight from the data. As we forge into the future of next-generation sequencing technologies, bioinformatics practitioners will continue to design, develop and employ new algorithms, that are efficient, accurate, scalable, reliable and robust to enable knowledge discovery on the projected exponential growth of raw data. To this end, data mining has been and will continue to be vital for analyzing large volumes of heterogeneous, distributed, semi-structured and interrelated data for knowledge discovery. This book is targeted to readers who are interested in the embodiments of data mining techniques, technologies and frameworks, employed for effective storing, analyzing, and extracting knowledge from large databases specifically encountered in a variety of bioinformatics domains, including but not limited to, genomics and proteomics. The book is also designed to give a broad, yet in-depth overview of the application domains of data mining for bioinformatics challenges. The sections of the book are designed to enable readers from both biology and computer science backgrounds gain an enhanced understanding of the cross-disciplinary field. In addition to providing an overview of the area discussed in Section 1, individual chapters of Sections 2, 3 and 4 are dedicated to key concepts of feature extraction, unsupervised learning, and supervised learning techniques"-- Provided by publisher "Data Mining for Bioinformatics enables researchers to meet the challenge of mining vast amounts of biomolecular data to discover real knowledge. Covering theory, algorithms, and methodologies, as well as data mining technologies, the book presents a thorough discussion of data-intensive computations used in data mining applied to bioinformatics. The book explains data mining design concepts to build applications and systems. It shows how to prepare raw data for the mining process and is filled with heuristics that speed the data mining process"-- Provided by publisher Covering theory, algorithms, and methodologies, as well as data mining technologies, this book presents a discussion of data-intensive computations used in data mining applied to bioinformatics. It explains data mining design concepts to build applications and systems.