Cancer Epigenetics

During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being developed and used for cancer therapy. Cancer Epigenetics presents in-depth discussions of DNA methylation alterations, histone and RNA modifications, and nucleosome remodeling, which are all intimately involved in the formation of tumors. It also analyzes metabolic influences on cancer epigenetics and advances in epigenetic cancer gene therapy. Discusses the Latest Advances in the Role of Epigenetics in Tumor Initiation, Progression, and Metastasis With stand-alone chapters written by research pioneers in the field, this definitive resource covers— DNA methylation and cancer Histone modifications in cancer Emerging areas of cancer epigenetics Epigenetics in the diagnosis, prognosis, and therapy of cancer Future directions in epigenetic cancer research Bringing together different topics into a single compilation, this text is a prime resource for those with interests ranging from the basic mechanisms of tumor biology to cancer therapy. It also serves as a core textbook for advanced courses with a focus on genetic diseases, molecular biology, and/or cancer. This seminal work answers the call for a thorough and authoritative reference that covers the critical and contemporary aspects of this revolutionary field. The role of epigenetics in cancer / Trygve O. Tollefsbol DNA hypomethylation in cancer / Peter L. Molloy DNA hypermethylation in oncogenesis / J. Tyson DeAngelis ... [et al.] Imprinting alterations in tumorigenesis / Jeremiah Bernier-Latmani and Phillip Shaw Proteins that modulate DNA methylation aberrations in cancer / Sabrina L. Walthall ... [et al.] The role of DNA methylation in cancer progression / Sang-Woon Choi and Simonetta Friso Alterations in histone acetylation in tumorigenesis / Sabita N. Saldanha and Trygve O. Tollefsbol Histone methylation and the initiation of cancer / Shi Huang The role of sirtuins in aging and tumorigenesis / Xiaohong Zhang ... [et al.] Proteins that alter histone modifications in cancer / Ada Ao and Jianrong Lu Dietary and environmental influences on histone modifications in cancer / Sabita N. Saldanha ... [et al.] Noncoding RNAs in cancer / Maciej Szymanski and Jan Barciszewski Cancer-linked DNA hyper- and hypomethylation: chromosome positional effects / Melanie Ehrlich Chromatin remodeling and cancer / Sari Pennings and Richard R. Meehan Poly-ADP-ribosylation in cancer / Rajeshwar N. Sharan Polycomb group proteins in tumorigenesis / Hanneke E.C. Niessen and Jan Willem Voncken Cancer and aging: the epigenetic connection / Craig A. Cooney DNA methylation in tumor diagnosis / Kavitha Ramachandran, Edna Gordian, and Rakesh Singal DNA methylation profiles as prognostic markers for cancer / Sam Thiagalingam and Panagiotis Papageorgis Diagnosing cancer using histone modification analysis / Mukesh Verma and Deepak Kumar Histone modifications in cancer biology and prognosis / Matthew A. McBrian, David B. Seligson, and Siavash K. Kurdistani Histone deacetylase inhibitors in cancer therapy / Aaron M. Sargeant ... [et al.] Methylation changes in neoplasia: diagnostic and therapeutic implications / Eleftheria Hatzimichael, Justin Stebbing, and Tim Crook Clinical trials and approved drugs for epigenetic cancer therapy / Debby M.E.I. Hellebrekers and Manon van Engeland Future directions in epigenetic cancer research / Jacob Peedicayil. Providing the most relevant information available, this work presents in-depth discussions of DNA methylation analysis and cancer, histone modifications and cancer, and other epigenetic aspects of cancer. Examining future directions in cancer research, this text offers a comprehensive overview of current and potential new epigenetics advancements. Back Cover Copy Catalog no. 45792, "Cancer Epigenetics Shelving Guide: Biological Sciences Elucidating" the most-recent advances in the genomic breakthrough of epigenetics, this cutting-edge work covers a wide array of aspects ranging from the role of epigenetics in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being developed and used for cancer therapy."Cancer Epigenetics" presents in-depth discussions of DNA methylation alterations, histone and RNA modifications, and nucleosome remodeling, which are all intimately involved in the formation of tumors. It also analyzes metabolic influences on cancer epigenetics and advances in epigenetic cancer gene therapy. With stand-alone chapters authored by research pioneers in the field, this definitive resource - discusses the recent advances in the role of epigenetics in tumor initiation, progression, and metastasis. It describes the importance of dietary and environmental factors on cancer epigenetics. It ranges from basic science to landmark discoveries in clinical practice. It highlights diagnostic and prognostic aspects of epigenetics in cancer and advances in gene therapy. It covers emerging aspects, such as RNA epigenetics, chromosomal position effects, epigenomics, and the role of polycomb-group genes in cancer."Cancer Epigenetics" is an indispensable reference for those with interests ranging from the basic mechanisms of tumor biology to cancer therapy. Serving as a core textbook for advanced courses with a focus on genetic diseases, molecular biology, and/or cancer, this seminal work answers the call for a thorough and authoritative book that covers the critical and contemporary aspects of this revolutionary field