Bone Marrow Pathology, 3rd Edition

Written by one of the world's leading haematologists, and three renowned histopathologists, Bone Marrow Pathology provides a comprehensive guide to the diagnosis of bone marrow disease. Now in its Third Edition, the text has been extensively revised and rewritten to reflect the latest advances in the field. Features:An extremely practical, up-to-the-minute text incorporating the new WHO classification of haematopoietic malignancies A comprehensive text written with great precision and clarity of style Incorporates a new section 'Problems and Pitfalls' - a unique section that will aid the working pathologist faced with a difficult situation An important text for the haematologist, histopathologist and haematopathologist with equal weight given to peripheral blood, aspirate, trephine biology and specialized techniques Extensively illustrated with many of the photographs being of paraffin-embedded sections Combines all the techniques now applied to bone marrow diagnosis, including immunocytochemistry, flow cytometery, immunohistochemistry and the diagnostic role of cytogenetic and molecular genetic analysis In this book we have set out to provide a practical guide to bone marrow diagnosis, based on an integrated assessment of peripheral blood and bone marrow aspirate films, trephine biopsy sections and various supplementary investigations. We believe that a trephine biopsy specimen should not be examined and interpreted in isolation. We have therefore discussed the clinical context of bone marrow diagnosis and have given equal weight to cytological and histological features. Since bone marrow diagnosis is no longer based on morphological features alone, this edition discusses in considerable detail the role of immunophenotypic, cytogenetic and molecular genetic analysis. We have dealt very fully with haematological disorders for which bone marrow examination is commonly performed. However, we have also sought to be as comprehensive as possible, including whatever information is available on uncommon and rare disorders so that the book will serve as a useful reference source. When possible, we have illustrated rare as well as common conditions and have cited the relevant scientific literature extensively. In this edition we have introduced a new section entitled 'Problems and pitfalls' which we believe will be of value. We have also expanded the description of technical methods. We hope that haematologists and histopathologists will continue to find this book a useful aid in their day-to-day practice and that trainees in these disciplines will find it indispensable Written by one of the world's leading haematologists, and three renowned histopathologists, Bone Marrow Pathology provides a comprehensive guide to the diagnosis of bone marrow disease. Now in its Third Edition, the text has been extensively revised and rewritten to reflect the latest advances in the field. Features: An extremely practical, up-to-the-minute text incorporating the new WHO classification of haematopoietic malignancies A comprehensive text written with great precision and clarity of style Incorporates a new section'Problems and Pitfalls'- a unique section that will aid the working pathologist faced with a difficult situation An important text for the haematologist, histopathologist and haematopathologist with equal weight given to peripheral blood, aspirate, trephine biology and specialized techniques Extensively illustrated with many of the photographs being of paraffin-embedded sections Combines all the techniques now applied to bone marrow diagnosis, including immunocytochemistry, flow cytometery, immunohistochemistry and the diagnostic role of cytogenetic and molecular genetic analysis During extra-uterine life haemopoiesis is normally confined to the bone marrow.