Designed to help students incrementally build their knowledge of fundamental concepts of medicinal chemistry and their applications to therapeutic decisions, it is progressively organized. Specific sections of the text have been updated to make potentially confusing concepts easier to understand. Numerous examples and review questions further reinforce learning and analytical skills. This updated and expanded edition of the popular textbook, Basic Concepts in Medicinal Chemistry , has been enhanced with new subject material, numerous self-assessment tools, and special features to advance and strengthen the learning process. New in the Third Edition Enhanced explanations, discussions, and examples in many key chapters Additional summary tables to help readers better select the proper drug binding interaction Expanded discussion on Pharmacogenomics, including multiple specific examples Updated examples throughout the text to include a wider range of drugs and drug classes Increased focus on application of concepts to therapeutic decisions and pharmacy practice "This text will focus upon the basic, fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The text will include numerous examples of each concept as well as review questions designed to help readers assess their understanding of these concepts. Each chapter will also include a section that focuses upon the application of the pertinent concepts to therapeutic decisions. The text is meant to be comprehensive in regards to the fundamental chemical concepts that govern drug action; however, it will not discuss every drug or drug class. Through conceptual discussions, examples, and applications, the text should provider with the knowledge and skills to discuss the pertinent chemistry of drug molecules"-- Provided by publisher This updated and expanded edition of the popular textbook, Basic Concepts in Medicinal Chemistry, has been enhanced with new subject material, numerous self-assessment tools, and special features to advance and strengthen the learning process. Designed to help students incrementally build their knowledge of fundamental concepts of medicinal chemistry and their applications to therapeutic decisions, it is progressively organized. Specific sections of the text have been enhanced to make potentially confusing concepts easier to understand. Numerous examples and review questions further reinforce learning and analytical skills. Cover Title Copyright TABLE OF CONTENTS ACKNOWLEDGMENTS PREFACE ABBREVIATIONS USED IN THIS TEXT INTRODUCTION FUNCTIONAL GROUP CHARACTERISTICS AND ROLES IDENTIFYING ACIDIC AND BASIC FUNCTIONAL GROUPS SOLVING pH AND pK SALTS AND SOLUBILITY DRUG BINDING INTERACTIONS STEREOCHEMISTRY AND DRUG ACTION DRUG METABOLISM STRUCTURE ACTIVITY RELATIONSHIPS AND BASIC CONCEPTS IN DRUG DESIGN WHOLE MOLECULE DRUG EVALUATION ANSWERS TO CHAPTER QUESTIONS
